Secondary Failure of Metformin Monotherapy Secondary Failure of Metformin Monotherapy in Clinical Practice Running Title: Secondary Failure of Metformin Monotherapy
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چکیده
This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisherauthenticated version will be available in a future issue of Diabetes Care in print and online at http://care.diabetesjournals.org. Diabetes Care Publish Ahead of Print, published online December 29, 2009
منابع مشابه
Secondary Failure of Metformin Monotherapy in Clinical Practice
OBJECTIVE We sought to document the secondary failure rate of metformin monotherapy in a clinical practice setting and to explore factors that predict therapeutic failure. RESEARCH DESIGN AND METHODS We studied 1,799 type 2 diabetic patients who, between 2004 and 2006, lowered their A1C to <7% after initiating metformin monotherapy as their first-ever anti-hyperglycemic drug. We examined all A1...
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OBJECTIVE To assess glycemic control and secondary failure in patients adding thiazolidinedione or sulfonylurea therapy to a metformin regimen in a managed care setting. STUDY DESIGN Retrospective cohort study using administrative claims data. METHODS Participants (mean age, 51.1 years; 55.4% female) were required to have at least 1 prescription claim for a sulfonylurea (n = 300) or a thiaz...
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